The NCI'S Genomic Data Commons (GDC) contains NCI-generated data from a number of cancer genomic datasets, including The Cancer Genome Atlas (TCGA) and Therapeutically Applicable Research to Generate Effective Therapies (TARGET). These datasets are harmonized so that the data can be directly compared.
The GDC has developed a unified standards-based data repository via several resources, which users can not only download and retrieve, but through which they can also contribute data to the GDC, use the GDC bioinformatics pipelines to process data. Resources are maintained in a secure data center which provides user support and documentation.
The primary goal of the GDC is to provide the cancer research community with a unified data repository supporting cancer genomic studies. The unified repository will provide a cancer knowledge network that enables the identification of low-frequency cancer drivers, assists in defining genomic determinants of response to therapy, and informs the composition of clinical trial cohorts sharing targeted genetic lesions.